Working areas of the high-performance center Single-Cell Technologies LZ-EZT

Single-cell analysis and characterization

• Investigation of tumor heterogeneity at the single-cell level for personalized therapies
• Physical and genetic single-cell phenotyping for tumor diagnostics and drug development
• Use of single-cell sequencing and liquid biopsy, in particular using the CTCelect technology for the isolation and analysis of circulating tumor cells (CTCs) from blood samples for metastatic diagnostics and monitoring

Automated tissue processing and cell isolation

• Enzyme-free tissue dissociation through technologies such as TissueGrinder and µTissueGrinder
• Automated sample processing platforms for clinical research and therapy
• Cell printing and tissue engineering as alternatives to animal testing and for the development of new cell therapeutics

High-throughput phenotyping and process control

• Faster single-cell analysis through high-throughput screening with AutoRAPID
• CTCelect for capturing and phenotyping rare circulating tumor cells for oncology research
• Implementation of process controls for tissue and sample quality assurance

Biobank integration and quality management

• Interfaces to the biobank for quality management and sample traceability
• Optimized process chains from the operating room to pathology to the biobank for the highest tissue quality

Personalized medicine and diagnostic development

• Development of cell-based methods for cancer therapy and drug development
• Single-cell-based tumor diagnostics and targeted analysis of tumor cells for precision medicine
• Analysis and validation of tumor cells and CTCs for targeted therapeutic approaches